Mednet Logo
Community

How would you approach adjuvant therapy for a patient with resected T4N1 high grade large cell neuroendocrine tumor of the cecum with adenocarcinoma component?

Pathology details: 75% high grade large cell neuroendocrine tumor of the cecum (20-30 mitoses per 10 hpf, Ki67 75%) and 25% adenocarcinoma. Patient has V600E mutation and is also MSI-H (loss of MLH1, PMS2). Stage pT4N1M0 (neuroendocrine staging).
1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · UH Seidman Cancer Center, Case Western Reserve University
Answered on

However the diagnosis of mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) requires that each component (NEC and adenocarcinoma) exceeds 30%, I will make sure with pathology again this case is not MiNEN. For most patients with apparently localized GEP NECs, or MiNEN we should proceed with adj...

Join for free or sign in to see the full answer