How would you approach adjuvant therapy for a premenopausal female with HR+, HER2+ breast cancer with N1mic disease?

Topics: Breast Cancer • Medical Oncology • Her2+ • HR+

Stage T1bN1mic

Answer from: Medical Oncologist at Academic Institution

This is a difficult case; I see why someone posed the question. I'd want to know more information: - how old is this premenopausal women? - what is the grade of the cancer?- how many lymph nodes were removed?With regard to adjuvant chemotherapy / anti-HER2 therapy:My first thought, ba...

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Medical Oncologist at Kettering Cancer Center
Thank you for your input; for discussion purposes,...

Medical Oncologist at Duke University Medical Center
This becomes a philosophical question...arguments ...

Answer from: Medical Oncologist at Academic Institution

Assuming that she has had breast surgery, the adjuvant chemotherapy that I would use in this is weekly paclitaxel at 80 mg/m2 x 12 weeks along weekly trastuzumab x 12 weeks followed every 3-week trastuzumab for a total duration of one year. This regimen with median follow-up of 6.5 years (Tola...

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Medical Oncologist at Springfield Clinic
Will the choice of chemo change if the patient is ...

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