How would you approach an elderly patient with early stage TNBC with node negative disease?

While patient age, comorbidities, and T stage could influence my recommendations, if I felt that the patient was in good enough shape to tolerate chemotherapy and that her risk of distant recurrence was high enough to warrant treatment (relative to her life expectancy), I would favor administering weekly paclitaxel (80 mg/m2) and carboplatin (AUC 2) on days 1, 8, and 15 every 4 weeks for 4 cycles (or days 1 and 8 every 3 weeks x 6 cycles) - thus 12 doses of treatment - with close monitoring for ...