How would you approach definitive nonsurgical management for biopsy-proven, localized small cell carcinoma of the prostate?

Topics: Radiation Oncology • Genitourinary Cancers • Medical Oncology

Would you give chemotherapy concurrently with radiation? Would you change your radiation dose?

Answer from: Radiation Oncologist at Community Practice

Rare disease and one patient we treated with cis plus etoposide with RT added with second cycle. Because of concern about unsampled mixed high grade histology we planned to treat to 70 Gy. No PCI as isolated brain relapse for pelvic small cell is not same as for small cell of lung

Comments

Medical Oncologist at Northwest Georgia Onc Center PC
Thanks for response. I seem to have mastered the r...

Answer from: Radiation Oncologist at Academic Institution

This is a rare disease where physicians will never have randomized trial data. However, multiple database studies have demonstrated survival benefit of adding local therapy (usually EBRT) in non-metastatic patients, especially fit enough for systemic therapy:2014 - https://www.ncbi.nlm.nih.gov/pubme...

Related Questions