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How would you approach definitive RT for mid-esophageal cancer in a patient who declines or cannot get chemotherapy?

2 Answers
Mednet MemberInvited Expert
Radiation Oncology · University of Florida
Answered on

RT alone. 70/35. I know, stop at 50. Pall RT. 

Mednet Member
Radiation Oncology · Vanderbilt-Ingram Cancer Center
Answered on

I am always reminded of RTOG 85-01 (Cooper et al., PMID 10235156) data in this clinical scenario. 

64Gy in 32Fx RT alone had a 0% 5-year rate of survival. If the matter is that the patient refuses chemotherapy, would try and inform him of that statistic (versus 26% with 50Gy + Chemo). 

If he cannot tolerate, then can proceed with RT to 64Gy, 70Gy as above, 50Gy (although all that data is with concurrent chemotherapy IIRC), or even just palliate at 30/10 or 37.5/15 when the patient develops symptoms.