How would you approach immunomodulatory treatment for systemic lupus associated protein losing enteropathy (PLE) in a patient whose clinical course has been complicated by significant infection?

Lupus protein-losing enteropathy (LPLE) is a rare manifestation of systemic lupus erythematosus (SLE). Therefore, the medical evidence for the "best treatment" of LPLE is only based on anecdotal reports, case series, and retrospective reviews.

Although the easy way out would be to say that a SQ or IV medication may be best (due to drug malabsorption concerns), I'm not so sure we can truly base this thought on medical facts. However, I'd love to hear if there is evidence for this. The response to oral steroids and immunosuppressants, such as azathioprine and cyclosporin, for treating LPLE is reported to be excellent (Al-Mogariren, PMID 21344315). It makes me wonder if one can have protein-losing enteropathy and its associated loss of proteins...