How would you approach iron supplementation in a beta thalassemia trait patient with restless leg syndrome?

Thalassemia does not alter my decision. I don't use PO iron for RLS as it is enormously more toxic. A ferritin of 75 is a light-year away from iron overload, and a total dose infusion of IV iron can be administered with impunity. This patient should be treated with a gram of LMW iron dextran over on...

It is fine to replenish iron if the patient is deficient, regardless of underlying thalassemia trait.