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How would you approach isolated inguinal lymph node squamous cell carcinoma of occult primary?

If workup is negative for a primary lesion, would you consider prophylaxis of potential primary sites (anus/vulva?), and would you treat bilateral inguinal/pelvic nodes or use directed RT to the isolated site of gross disease?
1 Answer
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Radiation Oncology · Memorial Sloan-Kettering Cancer Center
Answered on

Most of these are probably anal cancers, just based on the incidence and anatomy. One could certainly argue this either way (local only vs comprehensive). It is tempting to treat local only fields knowing that the salvage rate is probably high, but what has kept me from doing that is that comprehens...

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