Localized adenopathy in lupus is infrequent and the differential is broad including nonspecific reactive hyperplasia as part of underlying illness or local trigger, infectious (e.g., suppurative in association with staph or strep, MTB, atypical mycobacterium, fungal, etc), lymphoma (e.g., Hodgkin's ...

In our cohort, 15% of patients developed lymphadenopathy during their disease course mostly occurring within the first year of diagnosis. Half the patients presented with localized and half with diffuse lymphadenopathy. It was generally associated with other systemic lupus symptoms and serological a...