How would you approach management of a recurrent, high grade stromal sarcoma (ovarian origin) with progression on doxorubicin?
Stage IVB at diagnosis, ovarian primary arising in background of endometriosis. Initially responded to carbo/taxol/avastin, however recurred 2 months after discontinuation and progressed through Doxil.
ER/PR negative, no actionable mutations on germline/somatic tumor testing.