Topics:
Gastrointestinal Cancers • Medical Oncology
How would you approach patient with known Lynch Syndrome who developed a gall bladder cancer which on pathologic testing of the tumor by PCR and immunohistochemistry is pMMR and MSS?
Would you treat with immunotherapy ?
Answer from: Medical Oncologist at Community Practice
Assuming advanced/metastatic disease, for MSS disease, I would use frontline chemoimmuno therapy with cis+gem+durva/pembro. In this case, response to immunotherapy alone may not be comparable to MSI-high disease thus, hesitant to use pembro alone.
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