How would you approach patient with metastatic anaplastic thyroid cancer with NGS revealing only ARID1A mutation?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Answered on
It would be helpful to have the results of the entire NGS panel. Was ARID1A the only mutation noted on comprehensive tumor NGS? Was there any suggestion of MSI? ARID1A mutations usually result in either loss or decreased function of ARID1A which is a tumor suppressor. In-vitro and in-vivo data for P...
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