These are clinically challenging situations. I would image to see if there is gross vs. microscopic disease. I would also have a surgical colleague evaluate to see if re-resection is possible to remove gross disease if present and obtain negative margins. With respect to adjuvant radiation, histolo...

I largely agree with the considerations outlined by @Chirag S. Shah, though I would often favor preop RT 50 Gy followed by oncologic re-resection. The sensitive nature of this area makes the lower doses of preop RT much preferable to postop--but also makes it all the more valuable to optimize local ...