How would you approach synchronous early stage NSCLC adenocarcinoma and locally advanced symptomatic squamous head and neck cancer that is deemed nonresectable upfront?

I would appropriately stage both cancers. If there is no mediastinal involvement, and head and neck is locally advanced- would favor local treatment of lung cancer (surgical or SBRT- expect quick recovery and no delays) while planning for concurrent chemo radiation to head and neck.

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