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Pediatric Hematology/Oncology • Sarcoma • Wilms’ Tumors • Neuroblastoma • Chemotherapy • Pediatric Oncology • Hepatoblastoma
How would you approach the prevention of irinotecan-induced diarrhea in a patient who previously experienced a diffuse rash with cefixime?
What alternatives to cephalosporins would you consider? Do you consider allergy testing?
Answer from: at Academic Institution
Prevention of irinotecan-induced diarrhea commonly uses prophylactic oral cephalosporins such as cefixime or cefpodoxime, which suppress intestinal β-glucuronidase–producing bacteria that reactivate SN-38 glucuronide and drive delayed diarrhea [1]. In a patient with a prior diffuse rash t...
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