How would you approach the prevention of irinotecan-induced diarrhea in a patient who previously experienced a diffuse rash with cefixime?

Prevention of irinotecan-induced diarrhea commonly uses prophylactic oral cephalosporins such as cefixime or cefpodoxime, which suppress intestinal β-glucuronidase–producing bacteria that reactivate SN-38 glucuronide and drive delayed diarrhea [1]. In a patient with a prior diffuse rash to cefixime,...