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How would you approach the treatment of checkpoint-inhibitor-mediated temporal arteritis?

Is there role for IVIG? Would you alter the dose or time course of steroid therapy?
2 Answers
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Rheumatology · Johns Hopkins School of Medicine
Answered on

Temporal arteritis or GCA is a rare immune related adverse event due to immune checkpoint inhibitor (ICI) therapy. Corticosteroids are the first line treatment, along with holding the ICI. As there have been limited cases, there is not evidence for IVIG in this setting.

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Rheumatology · Washington University Physicians
Answered on

I agree; isolated cases with significant glucocorticoid adverse effects or evidence of additional large vessel involvement may require the addition of tocilizumab to obtain control of their disease.

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