How would you approach therapy for a patient with newly diagnosed non-GC DLBCL with previous anthracycline exposure?

For fit patients with prior anthracycline exposure for non-lymphoma healthcare who are fit for chemotherapy and with preserved LV function, I would recommend considering daR-EPOCH. The history of the regimen was its original development as treatment of relapsed lymphoma after 1L bolus doxorubicin, a...

In a young individual, I would be very reluctant to give an anthracycline, given previous exposure. It is preferred to use a chemotherapy combination that the patient has not been treated with previously, which may be associated with higher response rates. If transplant-eligible, a salvage regimen s...