How would you approach therapy for newly diagnosed germinal-center DLBCL who previously received an unknown systemic regimen with radiation for history of Hodgkin Lymphoma?

Topics: Hematologic Malignancies • Medical Oncology • Lymphoma • NCI-CCC Tumor Board Question • UC Irvine • NCI-CCC Lymphoma Tumor Board Question

Would you give R-CHOP without knowing if there was use of prior anthracycline?

Answer from: Medical Oncologist at Academic Institution

A lot of times, you can ask the patient if they received a red medication (doxorubicin) or if their hair fell out to determine prior anthracycline exposure. If you cannot confirm, I would assume that they received ABVD x 6 cycles. This would be a cumulative drug exposure of 300 mg/m^2. Depending on ...

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