How would you approach treating patients with biopsy-proven Hailey- Hailey disease refractory to multiple oral therapies (i.e tetracyclines, naltrexone, apremilast, glycopyrrolate, Cellcept), and requiring monthly steroid tapers for disease flares?

Topics: Dermatology • Bullous/Blistering Skin Disorders

The disease is responsive to ablative lasers however laser treatments are not an option.

Answer from: at Community Practice

I find Hailey-Hailey so challenging and so I often do throw the kitchen sink. Additional options behind what you mentioned include low-dose superficial XRT (recently reviewed in JAMA Dermatology), botulinum toxin, dupilumab, and oral jak inhibitors. My personal approach to those who respond to predn...

Comments

at NorthShore University HealthSystem
I've used all of above. Dupiluminab worked best bu...

at Forefront Dermatology
It worked very well for the two patients that I&rs...

Answer from: at Academic Institution

I personally have used botulinum toxin with excellent results.

Comments

at Forefront Dermatology
Awesome! How did you dose it and did the patient h...

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