How would you approach treatment in recurrent, localized rectal mucinous adenocarcinoma?
Would you consider repeating neoadjuvant chemo/RT? Does this, occurring in the context of Lynch Syndrome, change the treatment approach?
Answer from: Radiation Oncologist at Academic Institution
Well-differentiated mucinous rectal adenocarcinoma is relatively treatment resistant. In general if there is an in-field local recurrence after prior radiation (ie: is not a marginal miss), then that is very good evidence that it is radiation resistant.
There are many studies now showing that ...
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