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How would you escalate treatment for a pediatric patient with CNO with mandibular involvement and only partial response to biweekly TNFi?

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Mednet Member
Mednet Member
Rheumatology · University of Alabama Birmingham

If you are convinced of the correct diagnosis, then adding pamidronate to TNFi would be my suggestion. Additionally, you could maximize TNFi dose/interval (e.g., adalimumab 40 mg weekly).

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How would you escalate treatment for a pediatric patient with CNO with mandibular involvement and only partial response to biweekly TNFi? | Mednet