How would you manage a clinically inoperable, stage IIIB, MMR deficient uterine cancer?

Tumor felt to be technically unresectable due to extensive cervical/parametrial involvement. ER/PR and HER2 testing are pending.

1 Answer

Mednet MemberInvited Expert

Radiation Oncology · Abramson Cancer Center, University of Pennsylvania

Answered on

Tough situation and uncommon case.

If definitely inoperable, your options are to do preoperative systemic therapy or preoperative radiation therapy.

I often advocate for preoperative radiation therapy as these tumors tend to respond well to radiation, and you can save the standard-of-care chemothera...

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