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How would you manage a patient with LGI-1 encephalitis with faciobracial dystonic seizures who has not improved with 3 days of intravenous steroids?

How long do you monitor before re-treatment or moving to another agent like IVIG?
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What would be your approach in this situation?

21 physicians have voted

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1 Answer
Mednet MemberInvited Expert
Neurology · Yale University School of Medicine
Answered on

I typically treat with five days of IV steroids. In patients with autoimmune encephalitis, including LGI-1, who do not improve after five days of IV steroids, I would then move to IVIG or plasmapheresis (depending on patient comorbidities, availability of plasmapheresis, and severity of symptoms). If the patient had prior relapses of LGI-1 encephalitis or did not improve after all the above immunotherapies, rituximab would be the next agent I would consider.