Please select the option that best describes you:
Topics:
Hematologic Malignancies • Medical Oncology • Leukemia • Myeloproliferative Neoplasms • Hematology
How would you manage a patient with polycythemia and MPN symptoms (aquagenic pruritus, fatigue) that is JAK2/CALR/MPL negative but peripheral blood NGS positive for IDH2?
VUS is >50%. EPO level is normal. How do you delineate between MPN with a noncanonical mutation vs. CHIP incidental to polycythemia?
Answer from: at Academic Institution
I would approach this through the framing of a polycythemia/erythrocytosis workup and then consider MPN-related interventions if a diagnosis is made! This is an excellent review that provides an overview of erythrocytosis investigation (Noumani et al., PMID 38695361). In brief, I would be thinking a...
Sign in or Register to read more