How would you manage a patient with surgically resected T3N1 NSCLC who is found to have one small brain metastasis on staging MRI?

For adjuvant chemotherapy, this is a difficult question for which there is no evidence-based answer, really. The "textbook" answer is that this is metastatic disease, and adjuvant therapy has only been proven for early stage disease. However, since there is still a reasonable chance of a cure after ...

Concur with David. Pt is now NED, but at very high risk of recurrence elsewhere...

......Corey Langer

Agree as well - would typically offer these patients 4 cycles of an appropriate cisplatin doublet as adjuvant therapy.

Of relevance regarding adjuvant use of immunotherapy is ANVIL, the recent extension of the ALCHMEIST trial, which will assess nivolumab x 1 year vs observation as adjuvant therapy ...