How would you manage a solitary unresectable liver metastasis?

Excellent question!

Before starting any systemic treatments, has the patient undergone an MRI? Conducting an MRI prior to systemic therapy is crucial for accurately determining whether there are single or multiple liver metastases. The CAMINO study has shown that incorporating an MRI at the initial ...

In general, the local treatment options for unresectable solitary liver metastasis are:

1. External beam with photon (SBRT/IMRT/3-D)
2. Trans-Arterial Radio-Embolization (TARE) with Yttrium-90 microspheres
3. Proton beam therapy
4. Interventional ablation

The optimal treatment depends on the tumor size, locati...