How would you manage a spindle cell carcinoma of the Glottic (T1-T2N0) compartment and what fractionation would you use?
Is there a role for an altered fractionation regimen as an organ-preservation approach?
This pathological variant is uncommon and the older literature recommended mainly surgery. Is there any good literature on the control rates for RT vs. Surgery?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Medical University of South Carolina (Charleston)
Answered on
Though the cancer control rate is lower with this histology, definitive radiotherapy is still an option. I have treated patients with narrow field larynx only fields at 225 cGy/fx x 28 to 29 fractions (total dose 6300 to 6525 cGy). I ask my medical oncology colleagues to give weekly cisplatin 30mg/m...
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