How would you manage a young patient with HL who develops HF (EF < 30%) after 4 cycles of A+AVD who obtained a PET2 CR?

This is a tough case, and the management would depend on the extent of disease. Assuming that this is advanced stage HL, given the use of BV+AVD, I would be in favor of completing 6 cycles of therapy with a non-anthracycline-based regimen. You can consider consolidative radiation, but this would nee...

This is challenging and certainly uncommon. Given the young age, would doubt other causes of acute LV dysfunction but engaging cardio-oncology and ensuring a thoughtful workup for other causes, and intervention to promote cardiac remodeling, is critical.

But as to what to do with the lymphoma, I pre...