How would you manage a young patient with Sjogrens disease with extranodal marginal zone lymphoma involving bilateral parotid glands with bilateral cervical lymphadenopathy?  

This sounds rather like an extensive stage II disease with bilateral neck involvement.In this scenario, I would be very cautious recommending definitive radiotherapy.I would consider 2 x 2 Gy schedule, folllowed by Rituximab monotherapy.

For patients with low-grade NHLs (e.g., follicular lymphoma, marginal zone lymphoma), staging dictates treatment. If a patient has a localized process (e.g., contiguous stage I-II disease), then a definitive course of RT is typically recommended. The conventional approach is 24-30 Gy, though a dose-...