How would you manage biopsy-proven DLBCL in a patient who was treated with 6 cycles of R-CHOP 15 years ago for DLBCL?

It will be difficult to tell if this is a relapse vs. de novo DLBCL unless you have the old pathology slides available and if a skilled pathologist is able to tell. In general, patients with late relapses > 24 months from achieving remission have favorable outcomes with salvage chemotherapy and auto...