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How would you manage gout with hyperuricemia >10 mg/dl despite the maximum dose of allopurinol plus probenecid and a prior allergic reaction to pegloticase?

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Mednet Member
Mednet Member
Rheumatology · Wright State University

I am not sure what dose of allopurinol the patient is taking, how long he was on pegloticase, and if he had MTX or MMF with it. I can usually reduce the uric acid level with allopurinol and febuxostat. The key question here is whether the patient is taking the drug daily or not.

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Mednet Member
Mednet Member
Rheumatology · University of Chicago

I'm curious what the 'maximum' dose of allopurinol is. I've used as high as 800 mg a day. I also presume that the patient may not be compliant/taking the correct dose if their uric acid is not changing at all.

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