How would you manage multiple myeloma with a suboptimal response to frontline quadruplet therapy?

A suboptimal response, i.e. less than PR, to 4-drug induction is likely a poor prognostic sign, I just don't know how poor. This does not mean that you should follow induction with a tandem autologous transplant, CART, or bispecific as we don't know whether it's better than just moving forward with ...