How would you manage T3N0M0 sarcomatoid carcinoma of the prostate with adenosquamous differentiation s/p prostatectomy?

Sarcomatoid prostate cancer is an aggressive histological subtype. It may be locally aggressive, and post-operative PSA monitoring may be less helpful for this histologic subtype, which interferes with the usual trigger for initiation of salvage RT (Grignon, PMID 14976541). Despite the lack of high-...

Agree with Dr. @Dr. First Last. I would add that it may be worth regular imaging given the limitations of PSA in sarcomatoid/squamous differentiation. To highlight the aggressive nature of these, I recently saw one that went from NED after RP to >2 cm gross recurrence in a 3-month imaging interval. ...