How would you qualify and treat a patient with neutropenia, anemia, and abnormal NK cell population with normal trilineage marrow maturation?

Topics: Hematologic Malignancies • Medical Oncology • Hematology

Peripheral blood flow shows prominent NK cell population but marrow aspiration/bx shows normocellular marrow with trilineage hematopoiesis.

Answer from: Medical Oncologist at Academic Institution

I would run a molecular test to confirm that the clonality does not show a CD8-positive clone, as that is more common in LGL. The findings of a clonal NK population by flow cytometry would be enough, in the setting of neutropenia and anemia, to consider a diagnosis of NK cell LGL.

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Medical Oncologist at Thedacare Regional Medical Center-Appleton,Inc.
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