How would you respond to a patient with early-stage resectable NSCLC who has a clinical complete response to neoadjuvant chemo-IO, but subsequently declines surgery, not feeling it's necessary anymore?  

This is an unusual scenario to have a complete response by both CT and PET criteria together. I generally counsel patients regarding false-negative and false-positive error rates of the PET scan of approximately 10-15%. With regard to CT, slice selection may also miss residual millimeter-sized disea...