How would you respond to a patient with early-stage resectable NSCLC who has a clinical complete response to neoadjuvant chemo-IO, but subsequently declines surgery, not feeling it's necessary anymore?

This is an unusual scenario to have a complete response by both CT and PET criteria together. I generally counsel patients regarding false-negative and false-positive error rates of the PET scan of approximately 10-15%. With regard to CT, slice selection may also miss residual millimeter-sized disea...

I would explain to the patient that, based on the data we have today, systemic treatment alone has not been proven to cure a potentially curable cancer like this. There's a real concern that microscopic cancer cells may still be present at the time of surgery—and if those aren’t removed, there’s a s...