How would you treat a kidney transplant patient with both biopsy-proven BK nephropathy and recurrent membranous glomerulonephritis with nephrotic range proteinuria?
Answer from: at Academic Institution
This can be a challenging situation. The risk of graft loss is greater from the BK Nephropathy so would address this first. The first premise of treatment is reduction in immunosuppression, in a step wise fashion would decreae the mycophenolate followed by reduced targets for calcineurin inhibitor l...
Mostly concur with Dr. @Adey. I would generally shy away from cidofovir - the most recent consensus guidelines for BK management recommend against cidofovir due to evidence largely being poor for effectiveness. IVIg has not much better evidence but is also much less toxic.
Once BK is brought ...