How would you treat a large-cell neuroendocrine carcinoma of the breast with bulky axillary involvement with good response to neoadjuvant chemo followed by mastectomy/ALND?  

Would you consider traditional breast doses or higher? Would you consider treating only the axilla if the mastectomy specimen showed widely-negative margins?



Answer from: Radiation Oncologist at Community Practice

Answer from: Radiation Oncologist at Academic Institution