How would you treat a locally-recurrent extraosseous (pulmonary) Ewing sarcoma?
Ewing sarcoma of the right lung, status post bi-lobectomy and adjuvant VDC/IE, with recurrence 6 years in the right lung only. He has reached a cumulative doxorubicin dose of 300 mg/m2.
Answer from: Medical Oncologist at Academic Institution
It is possible to re-challenge the patient with the same regimen. Assuming EF and BNP are normal and can be followed, bolus Doxorubicin with Dexrazoxane would allow safe administration of additional doxorubicin. The alternative is to use high-dose Ifosfamide (14 g/m2/cycle). In the event of a good v...
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