How would you treat a patient with isolated CNS relapse of seminoma?
If CNS lesions were managed with surgery/radiation, is systemic therapy also warranted? If so, would you preferentially recommend 2nd line high dose chemotherapy or what clinical data would you use to inform that decision?
Answer from: Medical Oncologist at Community Practice
As one would expect there are really no reliable data to use to make decisions. I am assuming that there is not an significant elevation of HCG or AFP?. Typically I would first recommend engagement of a high volume center to review details of the case and get guidance. This is a highly unusual set...