How would you treat a patient with metastatic Leydig cell tumor of the testes with extensive lung and abdominal metastases (peritoneum, retroperitoneal LN and soft tissue) following orchiectomy and maximal surgical resection of abdominal disease?  

Nongerm cell tumors of the testis ( Leydig, Sertoli or sex cord stromal tumors) are not curable when metastatic when they are inoperable, as the case here. I would sequence his tumor to check for a targetable mutation, but this would provide a less toxic and hopefully more effective alternative to c...

I completely agree with Dr. @Lawrence H. Einhorn's response, but would add the caveat that it would be smart to ensure that the pathology report is correct - always worth a second pathologic opinion from a subspecialty g-u pathologist when an unusual diagnosis is made. Also worth confirming that AFP...