How would you treat a patient with metastatic RCC and significant baseline proteinuria after progression on immunotherapy?

- Tough situation no doubt. I would look for actionable genomic aberrations on NGS though limited in ccRCC.

- Consult with a nephrologist and depending on severity of proteinuria, closely monitor proteinuria (urine checks as well as serum protein/albumin levels) with use of VEGFRi (short-acting ones...