How would you treat a patient with metastatic RCC who developed posterior reversible encephalopathy syndrome (PRES) on a TKI-containing regimen?

Topics: Genitourinary Cancers • Medical Oncology • Renal Cell Carcinoma • NCI-CCC Tumor Board Question • Johns Hopkins • NCI-CCC GU Tumor Board Question

Would you consider re-challenging with a different TKI?

Answer from: Medical Oncologist at Academic Institution

PRES is a clinical-radiological diagnosis. The pathology (to my knowledge) is not yet clearly defined though is thought to be the consequence of vascular permeability compromise. There are known triggers of this disease including chemotherapy, auto-immune conditions and VEGF-TKI therapy, and hyperte...

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