How would you treat a pediatric embryonal rhabdomyosarcoma of the kidney with preoperative rupture s/p nephrectomy and getting VAC/VI chemotherapy?  

Would you treat this with whole-abdomen RT with a boost? What dose would you recommend? This would be Stage 1, Group 2 (R1 resection), low risk; but likely should be treated more like a Group 3 (R2 resection), intermediate risk given the preoperative rupture. ARST 0531 recommends using 24 Gy in 1.5 Gy/fx if doing whole abdomen RT, and typical dose for R1 resection is 50.4 Gy, but this would be limited by the bowel.



Answer from: Radiation Oncologist at Academic Institution
Comments
Radiation Oncologist at CCare
What liver constraints would you use? COG suggests...
Radiation Oncologist at St Jude Children's Research Hospital
We use a Whole Liver constraint of D50%
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