How would you treat a post-menopausal woman with recurrent breast cancer, T1bN0 HR+ (ER/PR > 90%), HER2- s/p lumpectomy and adjuvant RT with low oncotype of 6?

The question does not provide the details of recurrence as to whether this is a locoregional breast recurrence, with or without lymph node or chest wall involvement. Ipsilateral or contralateral or second primary? Prior lumpectomy margins, prior type, and extent of radiation therapy? Time to recurre...

In the CALOR trial that studied chemo vs. no chemo after resection of isolated locoregional recurrence, there is benefit of adjuvant chemotherapy. The 5-year HR for DFS with chemo was 0.59. The 5-year HR for OS with chemo was 0.41. The benefit was mainly seen in HR- patients. This patient has a very...