How would you treat a triple negative large (~ 6 cm) cancer in a woman in her second trimester of pregnancy?

There is data for the safety of anthracyclines in pregnant women. I would treat her with AC every three weeks for up to 4 cycles with close monitoring by a high risk obstetrician. There is also data for the safety of paclitaxel. I would treat her with chemotherapy till delivery and then proceed with further therapy (after suppressing laceration).

I would use growth factors only if needed. I don’t think there is enough data for the safety of Carbo (not is there plenty of convincing data for impr...