How would you treat a young patient who presents with coronary vasculitis and aortitis with persistently positive MPO but no other features of AAV?

Once infectious causes such as syphilis have been excluded, the most common causes of the combination of aortitis and coronary vasculitis would be Takayasu arteritis and IgG4RD. However, AAV can cause both aortitis and coronary vasculitis (albeit infrequently). Therefore, if there are no features of...

This is a difficult question for anyone to provide complete guidance since you are asking about treatment. The first question a provider has to ask is whether the treating doctor feels this is sufficient evidence to diagnose ANCA-associated vasculitis. All of us would love to invoke Takayasu arterit...