How would you treat a young patient with symptomatic Rosai-Dorfman disease who has recurrent, life-threatening pericardial and pleural effusions?

Topics: Hematologic Malignancies • Pediatric Oncology • Medical Oncology • Lymphoma • Hematology

CT scans show omental and pelvic disease.

Answer from: Medical Oncologist at Academic Institution

Rosai-Dorfman disease is the most tricky one of the top 3 histiocytosis (ECD, LCH, and RDD). It can behave as benign or as an aggressive disease. Given the rarity of the disease, there are no great prospective studies to guide optimal treatments. First-line treatment includes prednisone or other imm...

Comments

Medical Oncologist at Kettering Cancer Center
Thanks for a nice summary ! I started my patient o...

Medical Oncologist at University of Alabama Birmingham
Great! Let me know if I can be of any help down th...

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