How would you treat an older patient with stage IIC nonseminoma who is unfit for platinum chemotherapy due to comorbidities?

These are difficult questions to answer. The definition of a patient unsuitable for cisplatin in an elderly patient varies from oncologist to oncologist. Cisplatin + etoposide for 4 courses is the “standard“ therapy for patients over the age of 50. For elderly patients with poor performance status f...

I agree with Dr. @Dr. First Last. I think his first point is really important. Perhaps you could clarify what constitutes "unfit for chemotherapy" in this patient. For example, if he has renal dysfunction due to urinary obstruction, that can be addressed and would make him "fit" for cisplatin; if he...

I have a similar patient in his 50s with stage III seminoma (good risk) presented with hydronephrosis on the left, stent decompressed collecting system, and creatinine still 1.7 mg/dl, eGFR 47 ml/min. It seems like I'll have to do carboplatin for the first cycle and see where things flesh out as the...