How would you treat high grade urothelial carcinoma of the prostate with only HGUC with CIS in bladder?

The optimal peri-operative systemic therapy for non-contiguous UC involving the prostate is unclear due to lack of high-quality prospective data. One key aspect of staging and evaluation would be to further evaluate the depth of involvement and exclude stromal involvement by the prostatic UC. Prior retrospective studies have shown that prostatic stromal invasion is associated with an increased risk of regional lymph node involvement and significantly worse cancer-specific survival compared to pa...