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Topics:
Medical Oncology • Neuroendocrine Tumors
How would you treat metastatic small cell neuroendocrine carcinoma of unknown primary that fails to respond to 4 cycles of first-line platinum + etoposide + atezolizumab?
Poorly-differentiated, high-grade NEC, small cell histology, metastatic to the liver. NGS in this case shows RB1 alteration and SMARCA4 loss.